Shiny-DEG

Shiny-DEG performs differential gene expression analysis and visualization of RNA-seq data to identify differentially expressed genes in transcriptomic studies.


Key Features:

  • Multi-factor experimental design support: Supports multi-factor design experiments and adjustable analysis parameters to model complex experimental factors.
  • DEG identification using advanced statistical methods: Integrates advanced statistical methods for detecting differentially expressed genes from RNA-seq data.
  • Comprehensive visualization: Provides robust visualization capabilities to explore and present DEGs and expression patterns.

Scientific Applications:

  • Transcriptome differential expression: Identifies condition-specific differentially expressed genes for comparative transcriptomic analyses.
  • Genomics research: Supports genomic studies that require large-scale gene expression quantification and comparison.
  • Molecular biology: Enables investigation of molecular mechanisms through analysis of expression changes at the gene level.
  • Personalized medicine: Facilitates analysis of patient-specific transcriptomic differences relevant to precision medicine research.

Methodology:

Integrates advanced statistical methods for differential expression detection and accommodates multi-factor experimental designs, with included visualization of analysis results.

Topics

Details

Programming Languages:
R
Added:
1/18/2021
Last Updated:
2/16/2021

Operations

Publications

Wang S, Zhang Y, Hu C, Zhang N, Gribskov M, Yang H. Shiny-DEG: A Web Application to Analyze and Visualize Differentially Expressed Genes in RNA-seq. Interdisciplinary Sciences: Computational Life Sciences. 2020;12(3):349-354. doi:10.1007/s12539-020-00383-7. PMID:32666343.

PMID: 32666343
Funding: - National Natural Science Foundation of China: 31800781 - China Postdoctoral Science Foundation: 2018M631198 - Natural Science Basic Research Program of Shaanxi: 2018JQ1012