shinyDSP

shinyDSP guides interactive analysis and visualization of NanoString GeoMx Digital Spatial Profiling data through quality control, normalization, and differential gene expression analysis.

Key Features:

• Quality Control: Provides a guided workflow for quality control of GeoMx DSP data.
• Normalization: Performs normalization of GeoMx DSP data as part of the analytical workflow.
• Differential Gene Expression Analysis: Conducts differential gene expression analysis of GeoMx DSP data.
• Visualization: Generates visualizations of NanoString GeoMx Whole Transcriptome Atlas data with customizable output options.

Scientific Applications:

• Spatial Transcriptomics: Enables analysis of spatial transcriptomic profiles of distinct cellular microenvironments in human and mouse formalin fixed paraffin embedded tissue.
• GeoMx DSP Data Analysis: Facilitates analysis of NanoString GeoMx Digital Spatial Profiling data using tested methods.

Methodology:

shinyDSP is implemented as an R Shiny application.