silicon microprobes

silicon microprobes enable high-throughput extracellular neural recording with microfabricated multielectrode arrays to measure neuronal spiking and to integrate with optical methods such as optogenetics and fiber photometry.

Key Features:

• Open Source Dissemination: Shared designs and resources are provided via an online repository to support adoption and distribution.
• High Electrode Count: Arrays contain up to 256 electrodes for dense, simultaneous extracellular recordings across various brain regions.
• Integration with Optogenetics and Fiber Photometry: Designed for use with optical fibers to enable simultaneous optogenetic manipulation or fiber photometry for relating calcium activity to spiking.
• Mass Production Capability: In-house designs are fabricated and assembled by third-party companies to enable scalable production.

Scientific Applications:

• High-throughput recording in head-fixed animals: Dense extracellular recordings suitable for experiments in head-fixed preparations requiring many channels.
• Validation of fiber photometry: Simultaneous electrophysiological measurements enable validation of fiber photometry signals and correspondence between calcium activity and neuronal spiking.
• Multiregional neural recordings: Simultaneous sampling across various brain regions to study population-level neuronal dynamics.

Methodology:

Probes are designed in-house, fabricated and assembled by external companies, and distributed via an open online repository.