Simple Scattering

Simple Scattering centralizes correlated small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) datasets from lipid nanoparticle (LNP) screening experiments with standardized formulation metadata to guide LNP formulation development.

Key Features:

• Data Repository: Stores and shares groups of correlated scattering profiles obtained from LNP screening experiments.
• Standardized Metadata: Incorporates appropriate, standardized metadata describing LNP formulation parameters.
• Multi-technique Integration: Accommodates both SAXS profiles and correlated SANS datasets with systematic deuteration for additional contrast.
• Open Access: Provides an open, centralized resource for LNP structural data.

Scientific Applications:

• LNP Formulation Optimization: Guides the formulation of lipid nanoparticles with desired properties by providing centralized structural data.
• Structure-Function Relationship Analysis: Supports assessment of the relationship between LNP formulation, internal structure, and therapeutic efficacy.
• High-Throughput Screening Data Management: Enables collection and organization of thousands of SAXS profiles from diverse LNP formulations.
• Complementary Structural Analysis: Facilitates combined analysis of SAXS and SANS datasets for comprehensive LNP structural characterization.

Methodology:

Simple Scattering collects correlated scattering profiles from high-throughput workflows consisting of automated mixing, SAXS, and cellular assays, with SANS datasets where components are systematically deuterated for additional contrast.