SISTEMA

SISTEMA provides a quality-controlled, curated gene expression database of transcriptome datasets from human pluripotent stem cell (hPSC) lines and their derivatives to support standardized comparative analysis of gene expression across cell types, pathological states, and pharmacological interventions.

Key Features:

• Curated gene expression database: Aggregates curated transcriptome datasets and associated gene expression measurements.
• Standardization: All included transcriptomic data are generated and analyzed using a single, consistent experimental pipeline.
• Quality Control: Datasets undergo rigorous quality control measures to ensure accuracy and consistency of gene expression data.
• Comprehensive Coverage: Includes a wide range of hPSC lines and their derivatives.

Scientific Applications:

• Disease Modeling: Enables comparison of gene expression profiles across different pathological conditions to support disease modeling.
• Drug Discovery: Supports evaluation of pharmacological treatment effects on gene expression.
• Cell Therapy Development: Supports assessment of gene expression changes after specific treatments or under various conditions relevant to cell therapy.

Methodology:

Transcriptome datasets from hPSC lines and derivatives were generated and analyzed using a consistent experimental pipeline and subjected to rigorous quality control.