SITVITBovis

SITVITBovis aggregates genotyping and epidemiological data for Mycobacterium bovis to support characterization of geographic distribution, spoligotype diversity, phylogenetic sublineages, and host associations.

Key Features:

• Extensive Data Repository: Contains data on 25,741 isolates from 60 countries of origin and 75 countries of isolation, with annotated phylogenetic sublineages BOV_1, BOV_2, BOV_3, and BOV_4-CAPRAE.
• Spoligotype Patterns: Reports 1,000 spoligotype patterns, including 537 Spoligotype International Types (SITs) encompassing 25,278 clinical isolates and 463 orphan patterns.
• Cross-Database Compatibility: Enables comparison of SIT identifiers to SB numbers from the Mbovis.org database for cross-referencing and integration.
• Host and Geographic Information: Associates isolates with regions of isolation and host species to support analysis of geographic trends and host-specific patterns.
• Whole-Genome Sequencing Queries (Planned): A forthcoming version will include queries against whole-genome sequencing data.
• Additional Genetic Markers: Includes limited information on mycobacterial interspersed repetitive units–variable number of tandem repeats (MIRU-VNTR).

Scientific Applications:

• Epidemiology: Supports linking genotypes to geographic and host metadata for epidemiological analysis of bovine tuberculosis.
• Phylogenetic analysis: Enables investigation of phylogenetic sublineages and strain relationships, including BOV_1, BOV_2, BOV_3, and BOV_4-CAPRAE.
• Host dynamics and zoonosis studies: Facilitates study of transmission dynamics between animal and human hosts and host-specific patterns.
• Disease control and public health planning: Informs disease control strategies, public health planning, and the development of targeted interventions against Mycobacterium bovis.

Methodology:

Integration of genotyping data (spoligotypes, SITs, MIRU-VNTR where available) with epidemiological metadata and cross-referencing of SIT identifiers to SB numbers from Mbovis.org for comparative analyses.