snOPY

snOPY provides a curated database of small nucleolar RNAs (snoRNAs), their orthologues, gene loci, and target RNA modification sites (including rRNAs and snRNAs) to support comparative and functional studies of snoRNA-guided RNA modification.

Key Features:

• Extensive data repository: Contains 13,770 registered snoRNA genes, 10,345 snoRNA gene loci, and annotations for 133 target RNAs.
• Orthologue annotations: Includes orthologous snoRNA data across multiple species to enable comparative and conservation analyses.
• Target RNA annotation: Catalogs snoRNA target sites and associated modifications in rRNAs and snRNAs.

Scientific Applications:

• Comparative genomics: Cross-species analysis of snoRNA orthologues to assess conservation and evolutionary relationships.
• RNA modification studies: Investigation of snoRNA-guided nucleotide modifications in rRNAs and snRNAs.
• Evolutionary analysis of snoRNA genes: Examination of snoRNA gene loci and orthologue patterns to study evolutionary dynamics.

Methodology:

Systematic collection and organization of snoRNA gene, locus, orthologue, and target RNA annotation data.