SNPdb

SNPdb provides a comprehensive catalog of single nucleotide polymorphisms (SNPs) and other small-scale genetic variations, including insertions/deletions, microsatellites, and non-polymorphic variants, to support large-scale sampling designs for association studies, gene mapping, and evolutionary biology research and is maintained by the National Center for Biotechnology Information (NCBI).

Key Features:

• Integration with NCBI resources: Links SNP records to GenBank, PubMed, LocusLink, and Human Genome Project data to provide broader biological context.
• Multiple data formats: Complete database contents are available for download in various formats via anonymous FTP.
• Comprehensive coverage: Catalogs a wide array of genome variations, including SNPs, insertions/deletions, microsatellites, and non-polymorphic variants.
• Support for large-scale sampling designs: Provides variant information structured to support association studies, gene mapping, and evolutionary analyses.

Scientific Applications:

• Association studies: Identification and reference of genetic variants for linking alleles to diseases or traits in population-based analyses.
• Gene mapping: Localization of genes using detailed SNP positions and associated variant annotations.
• Evolutionary biology: Analysis of genetic diversity and evolutionary processes across populations and species using cataloged variants.

Methodology:

Data are maintained through submissions from researchers worldwide and integrated with other NCBI databases (GenBank, PubMed, LocusLink, Human Genome Project data) to enrich variant records.