SNPnexus COVID

SNPnexus COVID provides functional annotation and prioritization of genetic variants from COVID-19 patient genomes to support host genetics research into susceptibility and severity of SARS-CoV-2 infection.

Key Features:

• Variant annotation: Performs functional annotation of genetic variants identified in COVID-19 patient genomes.
• Underlying SNPnexus engine: Uses the SNPnexus software framework to aggregate annotation data and support variant interpretation.
• Functional implication analysis: Assesses potential functional consequences of variants to inform how they may influence disease susceptibility and severity.
• Clinical utility prioritization: Prioritizes variants with potential clinical relevance for prevention, management, or treatment of COVID-19.

Scientific Applications:

• Host genomics analysis: Analysis of host genetic variants to identify determinants of susceptibility to SARS-CoV-2 infection and variation in COVID-19 severity.
• Variant interpretation for translational research: Prioritization of clinically relevant variants to support prevention, management, and treatment research for COVID-19.

Methodology:

Integrates sequencing datasets from global COVID-19 patient genome initiatives and performs functional annotation of variants using the SNPnexus framework.