SOURCE

SOURCE aggregates and integrates gene annotations, published DNA microarray and cDNA microarray expression datasets, and GeneOntology annotations to support genome-scale functional genomics and expression analyses for human, mouse, and rat.

Key Features:

• Integrated Data Repository: Compiles GeneReports containing gene aliases, chromosomal locations, functional descriptions, and GeneOntology annotations.
• Gene Expression Insights: Curates published DNA microarray gene expression datasets to enable identification of co-regulated genes across tissues and conditions.
• Dual-Centric Pages: Provides gene-centric and cDNA clone-centric pages for analysis of cDNA microarray datasets.
• Dynamic Linking and Browsing: Implements dynamic links to individual gene and clone reports to support browsing of genomic datasets.
• Batch Interface for Large-Scale Analysis: Offers a batch interface to extract data for thousands of genes or clones and supports statistical analyses including functional attribute enrichment within gene clusters.
• Continuous Updates and Accuracy: Maintains updated information for human, mouse, and rat genes.

Scientific Applications:

• Functional Genomics: Integrates diverse datasets to aid interpretation of gene function and regulation at a genome-wide scale.
• Gene Expression Analysis: Enables exploration of expression patterns across conditions and tissues to identify co-regulation and expression networks.
• Statistical Genomic Studies: Supports large-scale statistical analyses of gene clusters, including enrichment assessments of functional attributes.

Methodology:

SOURCE aggregates and curates data from multiple external sources, curates published microarray gene expression datasets, provides gene-centric and cDNA clone-centric pages with dynamic linking, and implements a batch extraction interface for large-scale statistical analyses.