SpaDo

SpaDo performs multi-slice spatial domain analysis, including spatial domain detection, reference-based annotation, and clustering at both single-cell and spot resolutions to reveal biological insights from spatial transcriptome data.

Key Features:

• Multi-slice spatial domain detection: Identifies spatial domains across multiple tissue slices from spatial transcriptome data.
• Reference-based annotation: Annotates spatial domains using reference data to enable biological interpretation.
• Multiple slice clustering: Clusters multiple slices at both single-cell and spot resolutions.
• Cross-platform compatibility: Processes spatial transcriptome datasets from 7 sequencing platforms.

Scientific Applications:

• Multi-slice spatial transcriptome integration: Integrates and interprets spatial cellular landscapes across multiple tissue slices.
• Spatial domain characterization: Reveals novel biological insights in multi-slice spatial transcriptomes through domain detection and annotation.

Methodology:

SpaDo processes spatial transcriptome data and leverages reference-based annotation for multi-slice spatial domain analysis.