SPIKE

SPIKE provides a curated database of human signaling pathway interactions and pathway maps to support analysis of DNA damage response, cell cycle regulation, programmed cell death (apoptosis), and hearing-related functions.

Key Features:

• Highly Curated Interactions: The database contains literature-referenced, manually curated interactions specific to human signaling pathways.
• Pathway Maps: Pathways are presented as curator-derived map representations that depict interactions and regulatory relationships.
• Focused Pathways: Content concentrates on human pathways including DNA damage response, cell cycle regulation, programmed cell death (apoptosis), and hearing-related functions.
• Regular Updates and Expansion: The database is regularly updated to incorporate the latest research findings and to add new pathways.
• Exportable Formats: The complete database and individual pathway maps are exportable in several formats for use in external analyses.
• Analysis and Visualization Tool: An accompanying stand-alone software component provides dynamic visualization and analysis of pathway maps.

Scientific Applications:

• DNA damage response: Reference resource for curated interactions and pathway maps related to DNA repair signaling.
• Cell cycle regulation: Resource for pathways and interactions relevant to cell cycle control and its regulation.
• Programmed cell death (apoptosis): Repository of apoptotic signaling interactions and pathway representations for analysis.
• Hearing-related functions: Collection of pathways and interactions linked to auditory function and regulation.
• Hypothesis generation and experimental design: Dynamic pathway visualization and curated interaction data support hypothesis formulation and experimental planning.
• Interpretation of signaling networks: Curated interactions and pathway maps assist interpretation of complex signaling relationships in human biology.

Methodology:

Manually curated, literature-referenced annotation of interactions; curator-derived pathway map representation; export of database and pathway maps in multiple formats; accompanying stand-alone software for dynamic visualization and analysis.