ssbio

'Ssbio' is a software tool designed to tackle the challenges of working with protein structures at the genome-scale. It is a Python package that provides a framework to work with structural information in the context of genome-scale network reconstructions, which can contain thousands of individual proteins. It is an open-source tool that offers an automated pipeline to construct high-quality genome-scale models with protein structures (GEM-PROs). In addition, it provides wrappers to popular third-party programs to compute associated protein properties, and methods to visualize and annotate structures directly in Jupyter notebooks. By doing so, it lowers the barrier of linking 3D structural data with established systems workflows.

Topic

Systems biology;Genomics;Structure analysis

Detail

  • Operation: Protein structure analysis

  • Software interface: Command-line user interface

  • Language: Python

  • License: The MIT licence

  • Cost: Free

  • Version name: 0.9.9.1

  • Credit: Novo Nordisk Foundation Center for Biosustainability, the Swiss National Science Foundation, the National Institute of General Medical Sciences of the National Institutes of Health.

  • Input: -

  • Output: -

  • Contact: nmih@ucsd.edu

  • Collection: -

  • Maturity: -

Publications

  • ssbio: a Python framework for structural systems biology.
  • Mih N, et al. ssbio: a Python framework for structural systems biology. ssbio: a Python framework for structural systems biology. 2018; 34:2155-2157. doi: 10.1093/bioinformatics/bty077
  • https://doi.org/10.1093/bioinformatics/bty077
  • PMID: 29444205
  • PMC: PMC6658713

Download and documentation


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