SSRTool

SSRTool ranks and evaluates RNA secondary structure predictions using species-specific interpretability significance computed across four RNA structure–function aspects to support pre-experimental computational analyses.

Key Features:

• Ranking of Predictions: Ranks multiple secondary structure predictions for a given RNA sequence based on species-specific interpretability significance across four RNA structure–function aspects.
• Automated prediction and ranking workflow: Provides an automated workflow that integrates prediction generation and subsequent ranking of RNA secondary structures.
• Functional aspect inference: Infers functional implications of predicted RNA structures by interpreting rankings within species-specific contexts.
• Visualization outputs: Generates visual representations of predicted secondary structures and their species-specific rankings to facilitate interpretation.

Scientific Applications:

• Pre-experimental evaluation: Supports pre-experimental computational analyses and selection of candidate RNA structures for experimental follow-up.
• Benchmarking and validation: Facilitates benchmarking and validation of prediction methods, with case studies reporting species-specific rankings consistent with prediction F1 values.

Methodology:

Computes species-specific interpretability significance across four RNA structure–function aspects and uses these scores to rank multiple secondary structure predictions, supporting an automated prediction-and-ranking workflow.