STAB

STAB maps spatio-temporal single-cell transcriptomic landscapes of the human brain to characterize cellular and transcriptome architecture across development and in neuropsychiatric disorders.

Key Features:

• Single-Cell Transcriptomes: Incorporates single-cell RNA sequencing (scRNA-seq) data to provide gene expression profiles at the individual cell level.
• Comprehensive Coverage: Includes data from 42 distinct cell subtypes across 20 brain regions spanning 11 developmental periods.
• Spatio-Temporal Dynamics: Integrates spatial and temporal annotation to reveal regional heterogeneity and changes in cell types over developmental time.

Scientific Applications:

• Developmental neurobiology: Enables analysis of cellular composition and transcriptional changes across 11 developmental periods of the human brain.
• Neuropsychiatric disorder research: Supports investigation of molecular and cellular signatures associated with neuropsychiatric disorders by comparing normal and disease-related transcriptomic patterns.

Methodology:

Integration of single-cell RNA sequencing data with spatial and temporal annotations to construct a spatio-temporal cell atlas of the human brain.