St Jude Cloud

St Jude Cloud provides access to harmonized whole-genome, whole-exome, and transcriptome datasets and analytical resources to support genomic analyses of pediatric cancer and pediatric sickle cell disease.

Key Features:

• Extensive Genomic Data Repository: Harmonized genomic data exceeding 1.25 petabytes, including 12,104 whole genomes, 7,697 whole exomes, and 2,202 transcriptomes from more than 10,000 pediatric cancer patients and long-term survivors, plus genomic data from over 800 pediatric sickle cell disease patients.
• Dynamic Data Expansion: Regular uploads of new genomic data derived from St. Jude's prospective clinical genomics programs.
• Genomics Platform: Advanced cloud-based analysis of large-scale genomic datasets.
• Pediatric Cancer Knowledgebase: Integration of published data contributed by the global pediatric cancer research community.
• Visualization Community: Integrative multiomics visualizations for interpretation and exploration of complex genomic data.
• Subtype Classification: Supports classification of 135 pediatric cancer subtypes using gene expression profiling.
• Mutational Signature Mapping: Enables mapping of mutational signatures across 35 pediatric cancer subtypes.

Scientific Applications:

• Pediatric cancer subtype classification: Gene expression–based classification of 135 pediatric cancer subtypes.
• Mutational signature analysis: Mapping and analysis of mutational signatures across 35 pediatric cancer subtypes.
• Integrative multiomics interpretation: Interpretation of the interplay among whole genomes, whole exomes, and transcriptomes via multiomics visualizations.
• Pediatric sickle cell disease genomics: Analysis of genomic datasets from over 800 pediatric sickle cell disease patients.

Methodology:

Data harmonization; gene expression profiling for subtype classification; mutational signature analysis; integrative multiomics visualization; cloud-based analysis of large-scale genomic datasets.