StoneMod

StoneMod catalogs curated information on proteins that modulate kidney stone formation, consolidating experimentally supported data on proteins that promote or inhibit stages of calcium oxalate crystal development in nephrolithiasis and urolithiasis.

Key Features:

• Comprehensive Protein Data: Catalogs 47 modulatory proteins annotated by role: 10 affecting calcium oxalate crystallization, 16 affecting crystal growth, 13 involved in crystal aggregation, and 8 impacting crystal adhesion to renal tubular cells.
• Experimental Evidence: Each database entry is supported by published experimental studies validating the protein's modulatory role in stone formation.
• Integrated Cross-References: Entries include links to UniProtKB, Swiss-Prot, Human Protein Atlas, PeptideAtlas, and Ensembl for functional and structural context.

Scientific Applications:

• Molecular mechanism analysis: Enables investigation of protein-mediated modulation of calcium oxalate crystallization, growth, aggregation, and adhesion in kidney stone disease.
• Therapeutic target identification: Supports identification and prioritization of proteins as potential targets for interventions to prevent or treat nephrolithiasis and urolithiasis.
• Proteomics and biomarker research: Provides annotated protein entries and database cross-references to support proteomics studies and biomarker discovery.

Methodology:

Systematic gathering and manual curation of protein entries from published experimental studies with cross-references to UniProtKB, Swiss-Prot, Human Protein Atlas, PeptideAtlas, and Ensembl.