Stradwin

Stradwin quantifies cortical bone properties and maps osseous metastases from routine CT scans to support detection and longitudinal monitoring of prostate cancer bone disease.

Key Features:

• Sub-Voxel Accuracy: Provides sub-voxel precision in assessing cortical bone properties to detect subtle changes in bone tissue.
• 3D Bone Mapping: Generates 3D-rendered bone-maps from CT data to visualize cortical and trabecular bone structures.
• Serial Assessment Capability: Enables serial assessments for monitoring disease progression and showed perfect concordance with RECIST outcomes for osseous metastases.
• Sensitivity and Specificity: Initial evaluation reported a sensitivity of 70.7% and specificity of 73.1% for identifying suspicious areas on CT scans.
• Efficiency in Interpretation: Demonstrates substantially shorter interpretation times than traditional CT bone windows (P < 0.001).

Scientific Applications:

• Osseous metastasis assessment (prostate cancer): Applied in research and clinical evaluation of bone metastases in prostate cancer using CT-derived metrics.
• Early detection and monitoring: Supports baseline assessments and follow-up evaluations to detect and track progression of bone disease over time.

Methodology:

Creates 3D-rendered bone maps from CT data and assesses cortical bone properties at sub-voxel resolution for quantitative evaluation.