SubtiWiki

SubtiWiki provides integrated genomic, phenotypic, structural, and metabolic data for Bacillus subtilis to support research on gene function, protein structure, and systems-level biology.

Key Features:

• Conserved Genomic Organization Viewer: Enables exploration of conserved genomic structures and evolutionary conservation in Bacillus subtilis.
• Mutant Fitness Data Widget: Displays fitness data for all non-essential genes in Bacillus subtilis.
• Protein Structure Visualization: Provides protein structure visualizations including structure predictions and protein complex formations.
• Integration of Metabolites: Includes metabolites as entities to represent metabolic pathways and biochemical processes in Bacillus subtilis.
• Programmatic Access via API: Exposes an Application Programming Interface (API) for programmatic data access and integration.

Scientific Applications:

• Genomics: Facilitates analysis of conserved genomic organization and evolutionary conservation in Bacillus subtilis.
• Proteomics: Supports investigation of protein structural properties and protein complexes through structure predictions and visualizations.
• Structural Biology: Enables structural characterization and interpretation of protein models and complexes.
• Systems Biology: Supports systems-level studies by integrating genomic, fitness, structural, and metabolite data for Bacillus subtilis.

Methodology:

Includes a conserved genomic organization viewer; aggregates and displays mutant fitness data for non-essential genes; provides protein structure predictions and complex visualizations; integrates metabolites; and exposes an API for programmatic access.