SuperCYP

SuperCYP consolidates curated data on Cytochrome P450 enzymes (CYPs) and drug metabolism to support analysis of drug–CYP interactions, genetic variants, and structural information.

Key Features:

• Drug Interaction Data: Detailed records for 1,170 drugs encompassing over 3,800 drug–CYP interactions with literature references.
• SNP and Mutation Catalog: Approximately 2,000 single nucleotide polymorphisms (SNPs) and mutations organized by their impact on enzyme expression or activity.
• Homology-Modeled Structures: Homology-modeled CYP structures provided in PDB format for structural analysis.
• Drug Metabolism Pathways: Drug-cocktail metabolism analysis and pathway mapping to examine potential effects and alternative therapeutic strategies.
• Alignment and Variant Visualization: Sequence alignment of CYPs, visualization and annotation of SNPs and protein point mutations, and assessment of effects on enzyme activity with corresponding PubMed IDs.
• Coverage of CYPs: Curated literature coverage for 57 Cytochrome P450 enzymes (CYPs).

Scientific Applications:

• Pharmacogenomics: Enable correlation of CYP genetic variants with altered drug metabolism phenotypes.
• Drug Development: Support identification of CYP-mediated metabolic liabilities and drug–drug interaction risks.
• Personalized Medicine: Inform optimization of drug selection and dosing based on CYP variant and interaction data.

Methodology:

Text mining of literature concerning 57 CYPs and associated drugs followed by manual screening to extract facts about metabolism, SNPs, and their effects on drug degradation.