SuperTCM

SuperTCM integrates comprehensive Traditional Chinese Medicine (TCM) data to link active ingredients, biological targets, KEGG pathways, and disease associations for drug discovery and mechanistic analysis.

Key Features:

• Extensive Database Coverage: Covers 6,516 TCM drugs (herbs) derived from 5,372 botanical species.
• Active Ingredients and Targets: Contains 55,772 active ingredients linked to 543 biological targets.
• Pathway Integration: Integrates 254 KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways to map compounds to biological pathways.
• Disease Associations: Associates active ingredients and targets with 8,634 diseases.
• Multi-source Integration: Consolidates data from published TCM databases, the official Chinese Pharmacopoeia, and Kew's Medicinal Plant Names Service.

Scientific Applications:

• Drug Discovery: Links active ingredients to biological targets to support identification of candidate therapeutic compounds.
• Multi-component Drug Development: Enables analysis of potential synergistic effects among multiple TCM components and recipes.
• Pathway Analysis: Facilitates investigation of ingredient effects on biological processes via KEGG pathway mapping.
• Disease Research: Supports targeted research by associating ingredients and targets with specific diseases.

Methodology:

Data integration was performed via systematic curation of published TCM databases, the official Chinese Pharmacopoeia, and Kew's Medicinal Plant Names Service.