sv-callers

sv-callers implements a portable workflow to execute multiple structural variant (SV) detection tools in parallel on short-read whole-genome sequencing data for identification of somatic and germline SVs in cancer and other genetic studies.

Key Features:

• Parallel execution: Executes multiple structural variant detection tools concurrently to increase throughput and enable comparison of results.
• Support for short-read WGS: Targets SV detection from short-read whole-genome sequencing data.
• Multi-caller integration: Leverages diverse SV calling algorithms simultaneously to improve comprehensiveness and robustness of SV detection.
• Portability: Provides a workflow that can be deployed across different computing systems and platforms.
• Extensibility: Allows configuration and integration of additional analysis tools into the workflow.

Scientific Applications:

• Somatic SV analysis: Detection and characterization of somatic structural variants in cancer genomes.
• Germline SV discovery: Identification of germline structural variants in human genomic studies.
• Cross-platform SV analyses: Performing SV analyses across different computational platforms to support comparative studies.
• Genomic studies of disease: Supporting investigations into the role of structural variants in cancer and other genetic diseases.

Methodology:

Runs multiple structural variant detection tools in parallel and supports configuration and integration of additional analysis tools within a portable workflow for execution across computing systems.