SWISS-MODEL Repository

SWISS-MODEL Repository provides annotated 3D protein structure models generated by the automated SWISS-MODEL homology modeling pipeline using UniProtKB sequences and experimental template structures for structural interpretation of protein sequences.

Key Features:

• Extensive Model Collection: The repository houses over 400,000 models covering nearly 20% of Swiss-Prot/UniProtKB entries.
• Regular Updates: Models are built and refreshed using the latest sequence and template structure databases to maintain target coverage.
• Quality Assessment: Model reliability and accuracy are reported using QMEAN results for model quality evaluation.
• Improved Target Coverage: Enhanced strategies expand the set of core organism models and UniProtKB-based targets.
• Functional Annotations: Functional annotations are integrated with models to provide additional biological context.
• REST-API Implementation: A REST-API provides programmatic access to model coordinates enabling bulk downloads.
• Open Licensing Model: Model coordinates are provided under an open licensing model to permit reuse and integration.

Scientific Applications:

• Structural interpretation: Annotated 3D models support structural interpretation and analysis of protein sequences.
• UniProtKB-linked analyses: Coverage of Swiss-Prot/UniProtKB entries enables structural studies integrated with UniProtKB data.
• Programmatic integration: REST-API access and open licensing enable bulk reuse and incorporation of model coordinates into computational workflows.

Methodology:

Models are generated by the automated SWISS-MODEL homology modeling pipeline using UniProtKB sequences and experimental template structures, and model quality is evaluated with QMEAN.