Swiss-PdbViewer

Swiss-PdbViewer performs comparative protein modeling and structural analysis, providing a sequence-to-structure workbench and a client interface to SWISS-MODEL for generating and inspecting protein three-dimensional models for structural biology and mutagenesis studies.

Key Features:

• Comparative Protein Modeling: Generates template-based comparative models to support rational design and analysis of protein variants.
• Sequence-to-Structure Workbench: Builds three-dimensional models from amino acid sequences within a sequence-to-structure workflow.
• Structure Analysis and Manipulation: Provides tools to compare, color-code, annotate, and introduce point mutations in 3D protein models.
• Integration with SWISS-MODEL: Acts as a client interface to the SWISS-MODEL server to access automated comparative modeling services.
• Access to SWISS-MODEL Repository: Connects to the SWISS-MODEL Repository containing over 3,500 automatically generated protein models.

Scientific Applications:

• Rational Design of Mutagenesis Experiments: Supports design and structural evaluation of mutations by predicting and comparing modeled conformational changes.
• Structural Biology Research: Enables comparative structural analysis and interpretation of protein architecture and dynamics using modeled and template-derived structures.

Methodology:

Employs a sequence-to-structure approach that leverages comparative (template-based) modeling techniques to predict protein structures from known templates.