SYN-view

SYN-view employs phylogenetic analysis of gene synteny to compare biosynthetic gene clusters (BGCs) and identify genes associated with antibiotic resistance, complementing Antibiotic Resistant Target Seeker (ARTS) outputs.

Key Features:

• Phylogeny-Based Analysis: Performs phylogenetic analysis of gene synteny to compare BGCs and distinguish housekeeping genes from candidate antibiotic-resistance targets.
• Integration with ARTS: Extends and integrates with Antibiotic Resistant Target Seeker (ARTS) to provide phylogeny-informed synteny comparisons alongside ARTS target-directed genome mining outputs.
• Focus on Antibiotic Resistance: Targets identification and characterization of gene clusters linked to antibiotic resistance in microbial genomes.

Scientific Applications:

• Biosynthetic Gene Cluster Discovery: Supports identification of promising BGCs encoding natural products for novel antibiotic discovery by comparing synteny and phylogeny.
• Characterization of Antibiotic Resistance Mechanisms: Aids characterization of genes within clusters that contribute to antibiotic resistance by distinguishing resistance-associated genes from housekeeping homologs.

Methodology:

Performs phylogenetic analysis of gene synteny to compare gene clusters and distinguish housekeeping genes from resistant target genes.