SynergyFinder Plus

SynergyFinder Plus analyzes drug combination dose-response data to quantify synergy and sensitivity and to evaluate clinical potential in pre-clinical anticancer research.

Key Features:

• Extended Mathematical Models: Accommodates higher-order drug combination data analysis beyond pairwise combinations.
• Dimension Reduction Techniques: Implements dimension reduction to visualize the synergy landscape and identify patterns in high-dimensional datasets.
• Statistical Analysis with Confidence Intervals and P Values: Provides statistical assessment of drug combination synergy and sensitivity including confidence intervals and P values.
• Synergy Barometer: Harmonizes multiple synergy scoring methods to generate a consensus metric for synergy.
• Unbiased Evaluation of Clinical Potential: Evaluates synergy and sensitivity to support unbiased interpretation of clinical potential.
• Fast Annotation of Drugs and Cell Lines: Annotates drugs and cell lines with chemical and target information to support mechanism-of-action interpretation.

Scientific Applications:

• Oncology drug combination screening: Supports pre-clinical anticancer research to identify and prioritize combinatorial therapies.
• Pre-clinical drug discovery and development: Aids selection and evaluation of candidate drug combinations for therapeutic development.
• Analysis of complex dose-response datasets: Enables interpretation of high-dimensional drug combination dose-response data and synergy landscapes.

Methodology:

Integration of extended mathematical models for higher-order combinations, dimension reduction for synergy landscape visualization, statistical analyses including confidence intervals and P values, harmonization of multiple synergy scoring methods via the synergy barometer, and annotation of drugs and cell lines with chemical and target information.