SynToxProfiler

SynToxProfiler prioritizes drug combinations by integrating synergy, efficacy, and toxicity data to identify therapeutically optimal pairs.

Key Features:

• Integrated profiling: Integrates synergy, efficacy, and toxicity measurements for each drug combination.
• Selective efficacy scoring: Calculates selective efficacy as efficacy minus toxicity to quantify the therapeutic window.
• Prioritization algorithm: Ranks drug pairs based on combined synergy and selective efficacy metrics to highlight optimal therapeutic candidates.

Scientific Applications:

• Anti-Cancer Drug Combinations: Applied to 20 anti-cancer drug combinations tested on healthy control cells and T-cell prolymphocytic leukemia (T-PLL) patient cells to identify synergistic pairs with higher selective efficacy.
• Anti-Viral Drug Pairs: Applied to 77 anti-viral drug pairs tested in Huh7 liver cell lines with and without Ebola virus infection to identify drug pairs balancing efficacy and toxicity.

Methodology:

Integrates synergy, efficacy, and toxicity data; computes selective efficacy (efficacy minus toxicity); and ranks drug pairs according to combined synergy and selective efficacy metrics.