T-ARDIS

T-ARDIS links protein targets to adverse drug reactions by integrating drug-protein interaction and drug-ADR databases to identify statistically significant target–ADR associations for drug safety assessment.

Key Features:

• Integration of Databases: Combines data from drug-protein interaction databases and drug-ADR databases to identify associations between proteins and adverse drug reactions using drugs as connecting entities.
• Comprehensive Data Repository: Contains information on over 3,000 adverse reactions, 248 protein targets, and more than 17,000 pairwise interactions.
• Detailed Descriptions: Records include Uniprot ID, gene name, adverse effect, and drug name for each protein–drug–ADR entry.
• Flexible Search Capabilities: Entries can be retrieved by target Uniprot ID, gene name, adverse effect, or drug name.
• Statistical Association Analysis: Applies statistical analysis to detect significant associations between proteins and ADRs across integrated data sources.

Scientific Applications:

• Target safety prioritization: Enables early identification of protein targets associated with ADRs to inform pharmacology and toxicology assessments.
• ADR prediction for drug development: Predicts undesirable responses associated with protein modulation to support safer drug design.
• Computational research and data mining: Provides a curated dataset of protein–drug–ADR associations for bioinformatics analyses.

Methodology:

Statistical analysis of integrated drug-protein interaction and drug-ADR data to identify significant associations between proteins and adverse drug reactions.