T-Rx

T-Rx streamlines the processing of prescription records from electronic health records through an open-source R package that enables reproducible and scalable analysis across databases.

Key Features:

• Extraction and Imputation Module: Extracts and imputes prescription details, such as product strength and prescribed quantity, in UK-based EHR databases including UK Biobank and CPRD.
• Exposure Ascertainment Module: Converts discrete prescribing events into longitudinal exposure periods using one-line R commands.
• Phenotyping Module: Inputs prescriptions and returns phenotype dataframes for downstream analyses.

Scientific Applications:

• Genetic and epidemiological research: Supports studies of the genetic and epidemiological underpinnings of treatment outcomes through linkage between population-wide biobanks and electronic health records.
• Cross-study comparison: Enables scalable analyses and comparison of findings across studies through open, reproducible phenotyping algorithms.

Methodology:

T-Rx consists of three modules: an Extraction and Imputation Module, an Exposure Ascertainment Module, and a Phenotyping Module.