T1DBase

T1DBase integrates genetic, genomic, and gene expression data across human, mouse, and rat to support identification and contextualization of type 1 diabetes (T1D) susceptibility loci and related molecular signatures.

Key Features:

• Data Integration: Integrates genetic, genomic, and gene expression datasets across human, mouse, and rat to enable cross-species comparison.
• Genome-Wide Association Studies (GWAS): Provides curated summary data from four genome-wide association studies specifically relevant to T1D.
• HaemAtlas: Enables querying of gene expression levels in haematopoietic cells.
• Human T1D Susceptibility Loci: Maintains a manually curated table of human T1D susceptibility loci with annotations of genetic overlap with other related diseases.

Scientific Applications:

• Genetic risk factor identification: Support identification and validation of genetic risk factors associated with type 1 diabetes (T1D) using integrated datasets and GWAS summaries.
• Immune cell expression analysis: Enable analysis of gene expression patterns in haematopoietic/immune cells via HaemAtlas to investigate immune contributions to T1D pathogenesis.
• Cross-species comparative genomics: Facilitate comparative genomic studies across human, mouse, and rat to identify conserved genetic elements linked to T1D.
• Cross-disease genetic overlap analysis: Allow investigation of genetic overlaps between T1D and other autoimmune or related diseases using curated susceptibility loci annotations.

Methodology:

Integration of genetic, genomic, and expression datasets across species; curation of summary GWAS data from four studies; provision of HaemAtlas gene expression queries; and manual curation of human T1D susceptibility loci.