T3DB

T3DB consolidates biological, chemical, and mechanistic information on clinically significant toxins and their molecular targets into a unified electronic repository for toxicology research.

Key Features:

• Content scope: Contains over 2,900 small molecule and peptide toxins, 1,300 toxin targets, and more than 33,000 toxin–target associations.
• ToxCard entries: Each ToxCard comprises over 80 curated data fields describing chemical properties, descriptors, and toxicity values.
• Sequence and target data: Provides protein and gene sequences for toxins and their targets.
• Interaction and mechanistic data: Includes molecular and cellular interaction data, mechanistic descriptions, and literature references.
• Search capabilities: Supports extensive text searches, sequence analyses, chemical structure queries, and relational searches.
• Data model comparators: Data model and search types are similar to those used in the Human Metabolome Database (HMDB) and DrugBank.
• Curation: Content is manually extracted and verified from electronic databases, government documents, textbooks, and scientific journals.

Scientific Applications:

• Clinical metabolomics: Use of toxin and target data to interpret metabolomic profiles in clinical studies.
• Toxin target prediction: Identification and analysis of potential molecular targets for known toxins.
• Toxicity prediction: Informing computational and experimental assessments of toxicological risk.
• Toxicology education: Providing detailed mechanistic and reference information for teaching and training in toxicology.

Methodology:

Data were manually extracted and verified from electronic databases, government documents, textbooks, and scientific journals.