TADB

TADB catalogs Type 2 toxin–antitoxin (TA) loci and provides integrated predicted and experimentally validated data to support analysis of their distribution, genomic context, and evolutionary relationships across bacterial and archaeal genomes.

Key Features:

• Content: Contains 10,753 Type 2 TA gene pairs identified in 1,240 prokaryotic genomes and curated links to over 240 publications.
• Data types: Includes both predicted and experimentally validated Type 2 TA entries.
• Similarity search and sequence alignment: Provides similarity search and sequence alignment functionalities to identify homologous TA loci.
• Genome context browser: Offers a genome context browser to examine the genomic environment surrounding TA loci.
• Phylogenetic analysis: Includes phylogenetic analysis tools to explore evolutionary relationships among Type 2 TA systems.

Scientific Applications:

• Stress response and physiology: Enables investigation of Type 2 TA roles in stress response and bacterial physiology.
• Horizontal gene transfer and stabilization: Supports analysis of TA involvement in stabilization of horizontally acquired genetic material.
• Comparative genomics: Facilitates comparison of TA loci distribution across bacteria and archaea.
• Evolutionary analysis: Enables reconstruction and exploration of evolutionary relationships among TA families.

Methodology:

Compilation of predicted and experimentally validated Type 2 TA loci; sequence similarity searches and sequence alignments; genome context visualization; and phylogenetic analyses.