TAGOPSIN

TAGOPSIN integrates biological data from multiple public databases to assemble organism-centered datasets for comparative genomics, protein-structure analyses, and molecular evolutionary studies.

Key Features:

• Multi-Database Integration: Performs systematic retrieval from seven prominent public biological databases to consolidate related taxonomy, gene, ontology, protein, and structure information.
• Organism-Centric Data Assembly: Assembles organism-centered data into a single data warehouse for integrated analysis across data types.
• Versatility Across Organisms: Has been applied to eukaryotes, prokaryotes, and viruses, including integration of approximately 17,000 UniProt entries for Homo sapiens and 21 UniProt entries for human coronavirus.
• Comparative and Structural Analysis Support: Facilitates interspecific comparative analyses of protein-coding genes, identification of taxa-specific protein domains, and mapping to three-dimensional structures.
• Scope (Acronym): Covers TAxonomy, Gene, Ontology, Protein, Structure INtegrated data domains.
• Implementation: Implemented in Java.

Scientific Applications:

• Gene and genome analysis: Enables integrated retrieval of gene and taxonomy annotations for comparative genomic studies.
• Protein structural analysis: Supports linking protein sequences to domains and three-dimensional structures for structure-function investigations.
• Comparative genomics and molecular evolution: Provides consolidated datasets for interspecific comparisons of protein-coding genes and evolutionary analyses.
• Taxon-specific feature discovery: Aids identification of taxa-specific protein domains and structural patterns across organisms including viruses.

Methodology:

Retrieves interconnected records from selected public databases and organizes them into a unified data warehouse; implemented in Java.