TAPREG

TAPREG predicts TAP-mediated peptide transport and identifies CD8 T cell epitope precursors for MHC I antigen presentation.

Key Features:

• Prediction of TAP binding affinity: Predicts binding affinity between peptides and the transporter associated with antigen processing (TAP).
• Identification of CD8 T cell epitope precursors: Identifies potential N-terminal extended precursors of CD8 T cell epitopes that may be processed into shorter epitopes.
• Variable-length peptide analysis: Accommodates peptides of variable lengths, including typical ~9-residue peptides and extended precursors up to 16 residues.

Scientific Applications:

• Vaccine Development: Aids selection of peptides likely transported by TAP and presented on MHC I to elicit CD8 T cell responses.
• Disease Modeling: Informs models of antigen presentation in contexts such as viral infection and cancer by predicting peptides that reach MHC I.
• Immunotherapy Research: Provides insights into peptide transport and presentation relevant to the design or improvement of immunotherapies.

Methodology:

Analyzes peptides for their potential to bind and be transported by TAP, considering short peptides (~9 residues) and N-terminal extended precursors up to 16 residues, and predicts their likelihood of being shuttled from the cytosol into the endoplasmic reticulum for loading onto MHC I molecules.