TargetGeneReg

TargetGeneReg maps gene regulatory interactions mediated by p53, ΔNp63, RFX7, and cell cycle signaling by integrating gene expression and transcription factor DNA-binding data to characterize responses of coding and non-coding genes.

Key Features:

• Expanded Database: Includes coding and non-coding genes and annotations for transcription factors p53, ΔNp63, and RFX7.
• Integration of Multi-Omics Data: Combines gene expression profiling with transcription factor DNA-binding data for joint analysis.
• Dissection of Regulatory Effects: Identifies common and context-specific regulatory responses across cell types and treatment conditions.
• Candidate Identification and Validation: Facilitates selection of genes responsive to p53, ΔNp63, or cell cycle signals for downstream validation.

Scientific Applications:

• Cancer Research: Analyzes dysregulation of p53 and cell cycle pathways to support studies of tumor biology.
• Therapeutic Target and Biomarker Discovery: Supports identification of candidate therapeutic targets and biomarkers based on regulatory responses.
• Non-coding and Epigenetic Regulation Studies: Enables analysis of non-coding genes to investigate epigenetic and post-transcriptional regulatory mechanisms.

Methodology:

Integration of gene expression profiling with transcription factor DNA-binding data to determine gene-specific responses to p53, ΔNp63, and cell cycle signaling.