TarPan

TarPan visualizes targeted panel sequencing data to facilitate inspection and interpretation of copy-number changes, mutations, and structural events in cancer genomics.

Key Features:

• Data visualization: Provides visual representations of copy-number changes, point mutations, and structural events derived from targeted sequencing panels.
• Backend implementation: Implemented in R Shiny with an SQLite backend for data management and analysis execution.
• Panel adaptability: Accommodates analysis of any cancer-targeted sequencing panel, enabling panel-specific interpretation of genomic regions.
• Validation and use: Validated using publicly available datasets from follicular lymphoma, breast cancer, and multiple myeloma and applied in internal testing and peer-reviewed publications.

Scientific Applications:

• Oncogenic driver identification: Facilitates identification of recurrent mutations and copy-number alterations that may represent oncogenic drivers and therapeutic targets.
• Tumor-specific genomic analysis: Supports analysis of genomic alterations in tumor types including follicular lymphoma, breast cancer, and multiple myeloma.
• Clinical diagnostic support: Can be applied to interpretation of targeted panel results for cancers requiring rapid diagnostics, such as acute leukemia and diffuse large B-cell lymphoma.

Methodology:

Implemented in R Shiny with an SQLite backend; input data are generated by bioinformatic algorithms documented in the scientific literature.