TarpiD

TarpiD catalogs putative and validated targets of Piwi-interacting RNAs (piRNAs; 18–36 nucleotides) to link piRNA–PIWI protein interactions with gene regulation, transposon silencing, and genome integrity across nine animal species.

Key Features:

• Comprehensive Data Collection: A curated list of 28,682 piRNA–target interaction entries compiled from published literature covering hundreds of cell types and tissues across nine species and annotated by 15 distinct methodologies.
• Methodological Insights: Annotations distinguish between high-throughput and low-throughput approaches used for target identification and validation.
• Functional Annotations: Includes expression patterns of piRNAs and their targets, types of gene regulation (transcriptional and post-transcriptional), and reported target binding regions and biological functions.
• Disease Associations: Records reported links between piRNA–target interactions and various diseases to support molecular investigations of disease mechanisms.

Scientific Applications:

• Gene regulation studies: Enables analysis of piRNA-mediated transcriptional and post-transcriptional regulation of genes.
• Epigenetics and genome stability: Supports investigation of piRNA roles in transposon silencing and maintenance of genome integrity.
• Developmental biology: Facilitates exploration of piRNA functions across tissues and developmental contexts.
• Oncology and genetic disorder research: Provides data to examine associations between piRNA–target interactions and disease phenotypes.

Methodology:

Data were compiled from published literature and curated into 28,682 piRNA–target interaction entries annotated by 15 distinct methodologies, with distinctions between high-throughput and low-throughput identification and validation.