TCR

TCR quantifies geometries of T cell receptor (TCR) binding modes with peptide/MHC (pMHC) complexes to analyze how variations in binding geometry influence T cell signaling and structural recognition.

Key Features:

• Comprehensive Geometrical Quantification: Quantifies complex TCR–pMHC geometries beyond simple descriptors such as crossing angles to capture detailed binding-mode parameters.
• Class-Specific Binding Analysis: Distinguishes between class I and class II peptide/MHC complexes to reveal class-dependent differences in TCR access to peptide antigens.
• Enhanced Biological Insights: Relates geometric parameters of TCR binding modes to variations in T cell signaling, binding affinity outliers, and functional outcomes.
• Data-Driven Modeling: Supports modeling of structural properties of TCR–peptide/MHC complexes from sequence information.

Scientific Applications:

• Exploring TCR–pMHC Interactions: Enables detailed analysis of geometric parameters that govern TCR recognition of peptide/MHC complexes.
• Understanding T Cell Signaling Variability: Facilitates investigation of how differences in binding geometry contribute to variable T cell signaling and function.
• Structural Biology Research: Supports structural characterization and comparative analysis of TCR binding modes within immunological studies.

Methodology:

Computational quantification of TCR–pMHC geometries and modeling of structural properties from sequence information.