TCRBuilder

TCRBuilder predicts multi-state T-cell receptor (TCR) structures from paired α and β sequences to generate ensembles of binding-site conformations for analysis of TCR conformational diversity and polyspecificity.

Key Features:

• Multi-State Prediction: Generates ensembles of structural models representing multiple potential conformations of TCR binding sites.
• Paired αβ sequence input: Accepts paired alpha (α) and beta (β) TCR sequences as input to build structural models.
• Structural analysis of polyspecificity: Produces model ensembles that enable analysis of how binding-site conformational variability contributes to TCR polyspecificity and potential TCR–MHC interactions.

Scientific Applications:

• Explore Structural Variability: Investigate how different binding-site conformations affect TCR binding affinity and specificity.
• Enhance Predictive Models: Incorporate conformational diversity to improve predictions of TCR–MHC interactions.
• Facilitate Drug Design: Inform immunotherapy and vaccine design by revealing structural dynamics relevant to targeting TCR-mediated immune pathways.

Methodology:

Generates ensembles of structural models from paired α and β TCR sequences that represent multiple binding-site conformations.