TEDD

TEDD provides a curated database for exploring temporal gene expression and chromatin accessibility across developmental periods in human and model organisms, integrating 2,760 bulk samples and over 5.1 million single-cell sequencing studies.

Key Features:

• Extensive Dataset Integration: Integrates data from 2,760 bulk samples and over 5.1 million single-cell sequencing studies across 481 cell types, 79 tissue types, and 92 distinct timepoints.
• Gene Expression Profiling: Profiles temporal and cell-type-specific gene expression dynamics to identify genes involved in tissue and organ development.
• Chromatin Accessibility Analysis: Includes chromatin accessibility profiles alongside gene expression to elucidate regulatory mechanisms governing gene activity during development.
• Gene-Gene Interaction Mapping: Maps potential upstream and downstream interactions between genes, emphasizing shared biological processes and KEGG pathways.

Scientific Applications:

• Developmental Biology: Enables analysis of temporal and cell-type-specific expression patterns to study tissue and organ development.
• Disease Mechanism Elucidation: Supports identification of dysregulated genes and regulatory interactions relevant to disease mechanisms.
• Functional Genomics: Facilitates functional assignment of genes through integrated temporal expression and chromatin context.
• Therapeutic Target Discovery: Highlights genes with undefined biological functions as candidates for therapeutic target identification and pathogenesis studies.

Methodology:

Systematic curation and integration of bulk and single-cell sequencing datasets to perform unified analyses of gene expression and chromatin accessibility and to map gene-gene interactions within KEGG pathways.