TF-Marker

TF-Marker catalogs human transcription factors and related cell- and tissue-specific markers to support analysis of transcriptional regulation and marker identification.

Key Features:

• Extensive Data Collection: The database contains 5,905 entries manually curated from published literature.
• Classification System: Entries are classified into five categories: TFs (transcription factors that regulate markers), T Markers (markers regulated by specific TFs), I Markers (markers influencing TF activity), TFMarkers (TFs functioning as markers), and TF Pmarkers (TFs identified as potential markers).
• Comprehensive Coverage: The resource comprises 1,316 TFs, 1,092 T Markers, 473 I Markers, 1,600 TFMarkers, and 1,424 TF Pmarkers across 383 human cell types and 95 human tissue types.

Scientific Applications:

• Regulatory mechanism analysis: Supports investigation of cell- and tissue-specific transcriptional regulation by linking TFs to their target and interacting markers.
• Cellular differentiation and cell-type characterization: Enables identification of markers and TFs associated with specific cell types and differentiation states.
• Disease mechanism and pathology studies: Facilitates exploration of TF and marker roles in human disease contexts and pathological processes.
• Biomarker discovery for diagnostics and therapeutics: Aids identification of potential diagnostic or therapeutic markers and TF-based candidates relevant to personalized medicine.

Methodology:

Data were compiled through rigorous manual curation of published studies.