TFSyntax

TFSyntax catalogs transcription factor binding-site syntax across mammalian genomes to elucidate rules of TF cooperation that govern gene expression regulation, cellular homeostasis, and development.

Key Features:

• Extensive Mapping: Maps TF binding motifs for 1299 human transcription factors and 890 mouse transcription factors across 382 cells and tissues.
• Detailed Characterization: Reports motif positional preference, motif density, and motif colocalization within accessible genomic elements.

Scientific Applications:

• Transcriptional regulation research: Enables study of how TF cooperation governs gene expression, cellular homeostasis, and development.
• Regulatory variant interpretation: Supports investigation of how regulatory DNA variants contribute to disease.
• Cooperative TF interaction analysis: Facilitates analysis of motif colocalization and density patterns across distinct tissues and cell types.

Methodology:

Mapping of binding motifs for human and mouse transcription factors across numerous cells and tissues with analysis focused on motif positional preference, density, and colocalization within accessible genomic elements.