TFTG: A Comprehensive Database for Human Transcription Factors and Their Targets

TFTG provides a comprehensive collection of human transcription factor-target gene resources by integrating data from ChIP-seq, RNA-seq, motifs, and experimental confirmations, and performs functional and epigenetic annotations and regulatory analyses of transcription factors.

Key Features:

• Multi-strategy target gene identification: Target genes are obtained through fourteen identification strategies integrating ChIP-seq datasets, perturbation RNA-seq datasets, motifs, and experimentally confirmed relationships from available resources.
• Comprehensive functional annotation: The database performs comprehensive functional and epigenetic annotations of transcription factors.
• Regulatory analysis: TFTG conducts regulatory analyses of transcription factors and their target genes.

Scientific Applications:

• TF-target gene regulation research: TFTG serves as a resource for exploring human transcription factor-target gene regulations in gene expression regulation research.
• Disease mechanism studies: The database supports research on transcription factor contributions to disease occurrence and development through controlling cell-specific gene expression.

Methodology:

Target genes were identified by collecting and processing transcription factor-associated ChIP-seq datasets, perturbation RNA-seq datasets and motifs, and integrating these with experimentally confirmed relationships from available resources through fourteen identification strategies.