The GRID

The GRID archives and displays physical, genetic, and functional interactions among proteins and genes to support integration and analysis of molecular interaction networks.

Key Features:

• Interaction types archived: Stores physical, genetic, and functional interaction records for proteins and genes.
• Data integration sources: Integrates interaction data derived from literature curation and high-throughput studies.
• Visualization via Osprey: Integrates with the Osprey visualization system to generate graphical views and user-customized graphs that embed protein, gene, and interaction attributes.
• BioGRID linkage (v2.0): Linked to BioGRID release 2.0 containing over 116,000 interactions across Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens.
• Curation provenance: Interaction dataset content results from curation of more than 5,778 sources with particular emphasis on primary literature for Saccharomyces cerevisiae.
• Data formats: Provides datasets in tab-delimited text and PSI-MI XML formats.
• Pre-computed layouts: Produces pre-computed graphical layouts of interaction networks available in multiple file formats.

Scientific Applications:

• Interaction mapping and network analysis: Enables study of global network properties and complex biological networks using integrated interaction data and graphical layouts.
• Gene and protein function investigation: Supports inference of gene/protein function through curated physical, genetic, and functional interactions.
• Comparative interaction studies: Facilitates cross-species analysis using interaction datasets from S. cerevisiae, C. elegans, D. melanogaster, and H. sapiens.
• Evidence synthesis from literature: Aggregates curated interactions from primary literature to support evidence-based interaction analyses.

Methodology:

Integrates interaction data from literature curation and high-throughput studies; performs exhaustive curation from primary literature; generates pre-computed graphical layouts; interfaces with Osprey to produce user-customized graphs embedding protein, gene, and interaction attributes.