Thermometer

Thermometer predicts protein thermal stability from structural information to assess protein behavior under temperature changes.


Key Features:

  • Structural information utilization: Utilizes detailed protein structural information to evaluate determinants of thermal stability.
  • Computational prediction algorithms: Applies computational algorithms that analyze structural data to generate predictions of protein thermal responses.

Scientific Applications:

  • Protein Engineering: Predicts stability of engineered proteins to guide design for increased thermal robustness.
  • Biotechnology: Assesses enzyme and protein stability relevant to biotechnological processes operating at elevated temperatures.
  • Fundamental Research: Supports studies of the relationship between protein structure and thermal properties to inform protein dynamics research.

Methodology:

Computational algorithms analyze protein structural data to predict thermal stability and responses to temperature changes.

Topics

Details

Cost:
Free of charge
Tool Type:
web application
Operating Systems:
Mac, Linux, Windows
Added:
6/8/2022
Last Updated:
6/8/2022

Operations

Publications

Miotto M, Armaos A, Di Rienzo L, Ruocco G, Milanetti E, Tartaglia GG. Thermometer: a webserver to predict protein thermal stability. Bioinformatics. 2022;38(7):2060-2061. doi:10.1093/bioinformatics/btab868. PMID:35020787. PMCID:PMC8963285.

PMID: 35020787
PMCID: PMC8963285
Funding: - European Research Council: ASTRA 855923, IASIS 727658, INFORE 25080, RIBOMYLOME 309545