Thermometer
Thermometer predicts protein thermal stability from structural information to assess protein behavior under temperature changes.
Key Features:
- Structural information utilization: Utilizes detailed protein structural information to evaluate determinants of thermal stability.
- Computational prediction algorithms: Applies computational algorithms that analyze structural data to generate predictions of protein thermal responses.
Scientific Applications:
- Protein Engineering: Predicts stability of engineered proteins to guide design for increased thermal robustness.
- Biotechnology: Assesses enzyme and protein stability relevant to biotechnological processes operating at elevated temperatures.
- Fundamental Research: Supports studies of the relationship between protein structure and thermal properties to inform protein dynamics research.
Methodology:
Computational algorithms analyze protein structural data to predict thermal stability and responses to temperature changes.
Topics
Details
- Cost:
- Free of charge
- Tool Type:
- web application
- Operating Systems:
- Mac, Linux, Windows
- Added:
- 6/8/2022
- Last Updated:
- 6/8/2022
Operations
Publications
Miotto M, Armaos A, Di Rienzo L, Ruocco G, Milanetti E, Tartaglia GG. Thermometer: a webserver to predict protein thermal stability. Bioinformatics. 2022;38(7):2060-2061. doi:10.1093/bioinformatics/btab868. PMID:35020787. PMCID:PMC8963285.
PMID: 35020787
PMCID: PMC8963285
Funding: - European Research Council: ASTRA 855923, IASIS 727658, INFORE 25080, RIBOMYLOME 309545