thpdb

thpdb provides a curated database aggregating sequence, chemical, structural, and pharmacological data for FDA-approved therapeutic peptides and proteins to support bioinformatics, pharmacology, and drug development research.

Key Features:

• Content scope: Contains 852 entries comprising 239 FDA-approved therapeutic peptides and proteins and 380 drug variants.
• Data sources: Aggregates information from 985 research publications, 70 patents, and DrugBank.
• Sequence and chemical data: Provides primary sequences, chemical properties, and composition for each peptide and protein entry.
• Pharmacological and clinical annotations: Includes disease area, mode of activity, pharmacological class, pharmacodynamics, route of administration, toxicity, and target of activity.
• Physical and structural annotations: Records physical appearance and includes structural annotations for a significant subset of entries.

Scientific Applications:

• Bioinformatics: Enables computational analysis of peptide and protein sequences and properties for comparative and predictive studies.
• Pharmacology: Supports assessment of pharmacodynamics, pharmacological class, toxicity, and route of administration for therapeutic peptides and proteins.
• Drug development: Informs variant analysis, target selection, and formulation considerations using integrated sequence, chemical, and clinical annotations.
• Mechanistic and translational research: Facilitates study of mechanisms of action and interactions relevant to disease treatment and therapeutic design.

Methodology:

Data aggregation and curation from 985 research publications, 70 patents, and DrugBank to compile entries and associated sequence, chemical, structural, and pharmacological annotations.