THPDB2

THPDB2 provides a curated database of protein- and peptide-based therapeutics, compiling molecular, approval, and target information for FDA-approved and investigational proteins to support drug discovery and therapeutic research.

Key Features:

• Extensive coverage: Contains 6,385 entries including data on 894 FDA-approved therapeutic proteins and entries for investigational protein-based drugs.
• Therapeutic classes: Catalogs monoclonal antibodies, peptides, polypeptides, and biosimilar proteins.
• Detailed molecular information: Provides therapeutic name, amino acid sequence, physical and chemical properties, and route of administration for each entry.
• Biological targets and indications: Annotates targets such as receptors, factors, and other proteins and links therapeutics to diseases including cancers, infectious diseases, and immune disorders.

Scientific Applications:

• Drug discovery: Enables identification and comparison of protein- and peptide-based candidates for lead selection and optimization.
• Mechanistic and target studies: Supports analysis of therapeutic–target relationships for receptors, factors, and other protein targets.
• Translational research: Facilitates evaluation of approval status, sequence variation, and physicochemical properties for preclinical and clinical study planning.

Methodology:

Data are curated and aggregated from various sources with a focus on FDA-approved therapeutic proteins and investigational-stage protein-based drugs.