TIDB

TIDB consolidates curated gene and literature data on trained immunity from human, rat, and mouse to support functional and comparative analyses.

Key Features:

• Comprehensive Gene Repository: Curated collection of trained immunity-associated genes from human, rat, and mouse for cross-species analysis.
• Literature Evidence Integration: Curated literature references supporting the inclusion of each trained immunity gene.
• Reactome Pathway Over-Representation Analysis: Performs Reactome pathway over-representation analysis for gene sets associated with trained immunity.
• Gene Ontology Enrichment Analysis: Performs Gene Ontology enrichment analysis to identify enriched molecular functions, biological processes, and cellular components.
• Protein-Protein Interaction Subnetwork Reconstruction: Reconstructs protein-protein interaction subnetworks among proteins linked to trained immunity.

Scientific Applications:

• Innate Immune Memory Research: Supports investigation of mechanisms and gene roles in trained immunity and innate immune memory.
• Vaccine Design: Provides gene sets and pathway/GO analyses to inform vaccine design strategies.
• Therapeutic Development for Immune-Mediated Diseases: Supports identification of targets and interaction networks relevant to therapies for immune-mediated diseases.
• Comparative and Translational Studies: Enables cross-species comparison and translational interpretation between human, rat, and mouse data.

Methodology:

Manually curated gene–literature associations from human, rat, and mouse were integrated into the database; included computational modules perform Reactome pathway over-representation analysis, Gene Ontology enrichment analysis, and protein-protein interaction subnetwork reconstruction.