TOPSAN

TOPSAN facilitates annotation, integration, and mining of protein structures from structural genomics projects to support characterization of protein function and interactions.

Key Features:

• Automated Information Generation: Automatically generates initial annotations and summary information for protein structures.
• Collaborative Annotation: Supports contributions from multiple researchers for collective annotation of protein structures.
• Semantic Web Technologies: Employs semantic web technologies to link records to related databases and enrich database content.
• Data Integration and Mining: Enables integration of disparate datasets and supports data mining to extract patterns and relationships from structural and associated data.

Scientific Applications:

• Structural Genomics Annotation: Annotation and curation of protein structures produced by structural genomics initiatives.
• Protein Function and Interaction Characterization: Supporting characterization of protein functions and interactions for proteins that remain uncharacterized.

Methodology:

Leverages semantic web technologies to pre-populate records with automatically generated information, link entries to external databases, and enable data mining using conventional query languages.