ToxicoDB

ToxicoDB provides integrated access to curated toxicogenomic gene expression datasets from primary human and rat hepatocytes exposed to 231 potential toxicants to support analysis of molecular responses for chemical safety evaluation.

Key Features:

• Harmonized chemical annotations: Provides harmonized chemical annotations across studies to standardize compound identifiers and enable cross-study comparisons.
• Time- and dose-dependent plots: Generates time- and dose-dependent plots that illustrate compound effects across studies.
• Toxicity-related pathway analysis: Performs toxicity-related pathway analysis to identify molecular pathways associated with exposures.
• Curated gene expression datasets: Houses curated gene expression profiles from primary human and rat hepatocytes exposed to 231 potential toxicants.
• Integration with ToxicoGx: Uses the open-source R package ToxicoGx (GitHub) to underpin dataset generation.

Scientific Applications:

• Chemical safety testing and risk assessment: Supports analysis for chemical safety testing and risk assessment by linking molecular responses to exposures.
• Preclinical toxicity studies: Facilitates preclinical toxicity studies by providing standardized toxicogenomic datasets.
• Mechanistic toxicology: Enables elucidation of molecular mechanisms underlying toxic responses through pathway analysis.
• Adverse outcome identification: Aids in identifying gene expression signatures related to adverse outcomes following chemical exposure.

Methodology:

Data are curated and organized; datasets are generated using the open-source R package ToxicoGx (GitHub); analyses include generation of time- and dose-dependent plots and toxicity-related pathway analysis.